Abstract: Vitamin A vs. Restasis for dry eye

...And it's a tie!

Really!

Both Vitamin A and Restasis appear to have improved everything EXCEPT symptoms. (Oops, I take that back, sounds like staining didn't improve either.)

Am J Ophthalmol. 2008 Oct 8.
A Comparison of Vitamin A and Cyclosporine A 0.05% Eye Drops for Treatment of Dry Eye Syndrome.
Kim EC, Choi JS, Joo CK.

PURPOSE: To compare the efficacy of vitamin A (retinyl palmitate) and cyclosporine A 0.05% eye drops in treating patients with dry eye disease. DESIGN: Prospective, randomized, controlled, parallel group study. METHODS: A total of 150 patients with defined dry eye disease participated (50 in each treatment group). In three identical clinical trials, patients were treated twice daily with cyclosporine A 0.05%, four times daily with retinyl palmitate 0.05%, or with no eye drops. Adjunctive treatment with preservative-free artificial tears was undertaken four times daily in all groups. Corneal fluorescein staining results, Schirmer tear test (without anesthesia) results, tear film break-up time (BUT), dry eye symptom score, and impression cytologic analysis results were obtained before treatment and at the first, second, and third months after initiation of treatment. RESULTS: Both vitamin A eye drops and topical cyclosporine A 0.05% treatments led to significant improvement in blurred vision, tear film BUT, Schirmer I score results, and impression cytologic findings in patients with dry eye syndrome (P < .05). CONCLUSIONS: Both vitamin A eye drops and topical cyclosporine A 0.05% treatments are effective for the treatment of dry eye disorder.