Effects of postoperative cyclosporine ophthalmic emulsion 0.05% (Restasis) following glaucoma surgery.
Clin Experiment Ophthalmol. 2009 Dec;37(9):842-8.
Fakhraie G, Lopes JF, Spaeth GL, Almodin J, Ichhpujani P, Moster MR.
Wills Eye Institute, Philadelphia, Pennsylvania, USA.
Abstract
Purpose: To determine if postoperative topical cyclosporine 0.05% has any beneficial effect following trabeculectomy
Methods: This was an interventional, randomized, prospective, double-masked clinical trial of 44 consecutive patients with uncontrolled glaucoma requiring filtration surgery. Ocular surface disease index questionnaire and comprehensive ocular exam, including Schirmer's tear test 1, were performed. Patients underwent routine trabeculectomy, with or without phacoemulsification. The study group (n = 22) received cyclosporine 0.05%, and the control group (n = 22) received artificial tears. Patients were evaluated at 1 and 6 months post surgery. Outcome measures were intraocular pressure, success rate, bleb appearance, ocular surface disease index, Schirmer's tear test 1 and conjunctival inflammation.
Results: Thirty-nine patients completed the study (19 in the study group, 20 in the control group). The mean baseline intraocular pressure was 23.8 +/- 12.6 mmHg in the study group and 25.9 +/- 10.6 mmHg in the control group (P = 0.513). Mean intraocular pressure at postoperative month 6 was 14.88 +/- 6.2 and 14.62 +/- 5.46 mmHg in the study group and control group, respectively (P = 0.837). There was no statistically significant difference in the mean values of Schirmer's tear test 1 and the level of conjunctival hyperaemia between the two groups at baseline, months 1 and 6 post surgery. The treatment group had a statistically significant decrease in ocular surface disease index score at 6 months (P = 0.003), indicating less severity of dry eye symptoms and significant reduction in ocular pain.
Conclusions: Topical cyclosporine 0.05% had no effect on postoperative bleb function and intraocular pressure following trabeculectomy, but improved subjective ocular surface symptoms in these patients.
1 comment:
My dry eye problem started after laser surgery and, after a couple of years of working to get it under control, I just had cataract surgery and it's back again. One thing about Restasis. I was given it several times by eye doctors and really had nothing from it until I read the insert from the pharmacist. It said to add the drop, close the eye and use your hand to "Press"it against the eye for a minute or two. Bingo!! It works! I mentioned it to my eye doctors and they never heard of that, so I'm assuming that the info isn't widespread. So, all of you getting nothing out of your outrageously expensive prescriptions of Restasis, try that. It certainly worked for me. Good luck.
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