Invest Ophthalmol Vis Sci. 2010 Dec 22. [Epub ahead of print]
Ibrahim OM, Dogru M, Ward SK, Matsumoto Y, Hitomi Wakamatsu T, Ishida K, Tsuyama A, Kojima T, Shimazaki J, Tsubota K.
Johnson & Johnson Ocular Surface and Visual Optics Department, Keio University School of Medicine, Tokyo, Japan;
To evaluate the specificity and sensitivity of strip meniscometry testing (SM) in conjunction with tear function tests in the diagnosis of dry eye (DE) disease and to investigate the effect of SM on reflex tearing.
One hundred and seven left eyes of 107 patients with definite DE disease according to the Japanese dry eye diagnostic criteria and 68 left eyes of 68 age and sex matched control subjects were studied. Tear meniscus height (TMH) measurements, fluorescein tear film break-up time (FTBUT), fluorescein (F), Rose Bengal (RB) staining and Schirmer's test-1 (ST) were also performed. The assessment of reflex tearing before and after SM application was assessed with a graticule scale at slit-lamp and by Visante optical coherence tomography. The sensitivity and specificity of SM alone and in combination with tear function tests were also sought.
The SM scores, TMH measurements, FTBUT values and ST values were significantly lower in dry eye patients compared to the controls (p< 0.001). The RB and F staining scores were significantly higher in the dry eye group than in the control group (p < 0.001). SM strips didn't induce significant changes in relation to reflex tearing. SM had an acceptable sensitivity and specificity.
Strip meniscometry is a swift, noninvasive and promising method for assessing the tear meniscus volume. The combined SM and FTBUT examination appears to be a sensitive approach in assessment of dry eye disease.