To compare the efficacy of 3 different artificial tears (AT) acting primarily in one of the 3 tear film layers (Tears Again®, lipidic; Opticol®, aqueous; Optive®, mucin) in recovering the tear film changes in patients with dry eye symptoms due to external causes.
A total of 27 patients, with dry eye symptoms associated with extra hours of computer or contact lenses use, were randomized to 4 treatment groups: A received Tears Again®; B received Optive®; C received Opticol®; D received no treatment (control). Patients were observed in 3 visits: day 0, day 7, and day 30. Tear break-up time (TBUT) and Schirmer tests and the Ocular Surface Disease Index were performed. Data analysis was performed.
There were no significant differences between the groups. From day 0 to day 30, there was a decrease in the number of eyes with abnormal TBUT (not significant) and Schirmer (significant in A, B, D; p<0.031). There was an increase in the average TBUT for all groups (significant in A, C; p<0.001) and a decrease in the average Schirmer value in groups B, C, and D (not significant) and an increase in group A (p=0.002). There was a decrease in the average Ocular Surface Disease Index value in all groups (p<0.045).
All AT were efficient at recovering the tear film, but those acting primarily on the internal and intermediate layer led to a mild decline on lachrymal production. An association of different kinds of AT acting on each layer can be the best treatment for corneal surface diseases affecting eye lubrication.
Eur J Ophthalmol. 2011 Feb 4. pii: B27977C1-AD35-487C-9E0F-E71B087DAEE6. [Epub ahead of print]
Calvão-Santos G, Borges C, Nunes S, Salgado-Borges J, Duarte L.
Ophthalmology Department, Centro Hospitalar de Entre o Douro e Vouga-Unidade de Santa Maria da Feira, Santa Maria da Feira - Portugal.