Wednesday, October 16, 2013

Abstract: Autologous serum eyedrops - impact on signs & symptoms of DES

To assess the impact of autologous serum (AS) eye drops on the ocular surface of patients with bilateral severe dry eye and to draw a comparison between the clinical and laboratory examinations and the degree of subjective symptoms before and after serum treatment.
 Materials and methods:
A three-month prospective study was conducted on 17 patients with severe dry eye. AS eye drops were applied a maximum of 12 times a day together with regular therapy. Dry eye status was evaluated by clinical examination (visual acuity, Schirmer test, tear film breakup time, vital staining, tear film debris and meniscus), conjunctival impression cytology (epithelial and goblet cell density, snake-like chromatin, HLA-DR-positive and apoptotic cells) and subjectively by the patients.
The application of AS eye drops led to a significant improvement in the Schirmer test (p<0.01) and tear film debris (p<0.05). The densities of goblet (p<0.0001) and epithelial cells (p<0.05) were significantly increased, indicating a decrease of squamous metaplasia after AS treatment. A significant decrease (p<0.05) was found in the number of apoptotic, HLA-DR-positive and snake-like chromatin cells on the ocular surface. A significant improvement was found in all evaluated subjective symptoms. Altogether, the clinical results were improved in 77%, the laboratory results in 75% and the subjective feelings in 63% of the eyes.
We found that three-month AS treatment led especially to the improvement of ocular surface dryness and damage of the epithelium. The improvement of dry eye after AS treatment correlated well with the clinical, laboratory and subjective findings. From the patients' subjective point of view, the positive effect of AS decreased with time, but still persisted up to three months after the end of therapy.
Curr Eye Res. 2013 Sep 27. [Epub ahead of print]
Jirsova KBrejchova KKrabcova IFilipec MAl Fakih APalos MVesela V.
Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Disorders, General Teaching Hospital and First Faculty of Medicine Charles University in Prague , Czech Republic .

1 comment:

Anonymous said...

I am a long term sufferer of severe dry eye syndrome and have tried everything including the serum drops. I would like to know who these folks are that benefitted from serum drops. It's amazing in this day and age of science and medicine that there still is not a cure or even something that provides relief for more the ten minutes. This condition has caused me to become very depressed, unsocial, and cannot work anymore since my job requires use of a computer. I don't know why I am even posting this because like everything else related to this condition it does NOTHING!!
I do feel for other patients and hope someday before we die that something becomes available. There is no quality of life suffering from this condition.